Table of Contents

What makes Hair Growth+ inCLINIC unique?

Hair Growth+ inCLINIC is the only Proteoglycan Replacement Therapy on the market, and it is scientifically proven being a drug-free, completely safe, and side effect free method of increasing the concentration of specific hair follicle proteoglycans and hereby normalising the Hair Growth Cycle and supporting normal healthy hair growth.

How long does it take before patients start to notice a difference in their hair?

Most Hair Growth+ inCLINIC users start to see a difference after 2-3 months of proper use on the recommended daily intake.

Does the use of Hair Growth+ inCLINIC lead to improved hair growth for eyebrows?

Marilex-P® is unlikely to have any material effect on eyebrow or eyelash regrowth. However, some women have reported longer eyelashes and eyebrows and we can only attribute such subjective reports to the proximity of the eyes to the scalp where a partial knock on effect may be observed in some users. However, our advice is always to refrain from making any clinical claim that relates to eyebrows or eyelashes.

Is Hair Growth+ inCLINIC FDA-approved?

The legal framework in the US does not allow to register food supplements with the FDA – it is the manufacturer’s responsibility to ensure that their product is compliant with FDA regulations. The product is fully compliant with FDA; manufactured in an approved facility, packed in a compliant packaging and marketed inside the regulations monitored by the FDA for the US.

Can Hair Growth+ inCLINIC help to treat any/all types of hair loss?

Hair Growth+ inCLINIC by Nourkrin may be able to encourage hair growth and improve the hair loss situation no matter the cause, as it targets the Hair Growth Cycle that is always negatively affected in all types of hair loss.

However, we’d still recommend the opinion of a medical professional for a more complete and thorough diagnosis of the hair loss severity, which in turn affects the extent to which Hair Growth+ inCLINIC is able to help alleviate the problem.

Does Hair Growth+ inCLINIC or Marilex/Marilex-P specifically help to treat or improve Trichodynia caused by Telogen Effluvium?

As such, there are no direct clinical studies that determine whether Hair Growth+ inCLINIC or Marilex/Marilex-P help treat or improve this condition. However, as one of the factors that causes Trichodynia (hair pain) exhibited in patients suffering diffuse alopecia is “perifollicular inflammation”. The key proteoglycans in Marilex/Marilex-P are helpful in providing anti-inflammatory properties by downregulating the expression of several proinflammatory cytokines and inhibiting the adhesion of polymorphonuclear leukocytes by downregulating the expression of intercellular adhesion molecules.

Therefore, in a nutshell, whilst Hair Growth+ inCLINIC or Marilex/Marilex-P may not directly offer pain relief associated with Trichodynia, it helps alleviate some of the pain related symptoms indirectly by reducing the inflammation that contributes to it. As such, it is worth trying it with some patients and monitor if symptomatic relief is provided to the patient.

About Marilex-P

What is the bioavailability of Marilex®-P?

Hair Follicle Relative Bioavailability Studies have been conducted based on Fluorescent Spectroscopy labelled with various staining methods e.g. Pisum Sativum Agglutinin (PSA), which mainly decorates the dermal compartments of surrounding skin and hair follicles.

The relative increase in fluorescence translates into a value and a bioavailability result is extrapolated.
This has produced reproducible measurements.
An average value of 67% is attributed to Marilex-P® for a single bolus dose.
Repeat dosing causes the relative fluorescence to increase gradually because the t half-life is prolonged and nonlinear.

Serum Bioavailability studies have not been robustly conducted for Marilex®-P post investigative studies as there is no clear distinctive marker for the Marilex® complex in the blood stream and as such the data is non reproducible with significant deviation.

Are there any papers detailing clinical studies done with a higher dosage of Marilex®-P?

As highlighted above in relation to bioavailability, repeat dosing has a cumulative effect on Proteoglycan Concentrations in and around the hair follicle (dermal ECM, outer root sheath, inner root sheath and dermal papilla).

As such our R&D department has conducted the following internal studies to ascertain the superior efficacy of Marilex®-P over Marilex®:

Relative Bioavailability of Marilex®-P exceeds that of Marilex®
Cumulative fluorescence of Marilex®-P with repeat dosing in invitro epithelial cell lines clearly demonstrates:
Significant accumulation of proteoglycans in the dermal papilla compartment of the follicle.
More rapid accumulation of proteoglycans in the inner and outer root sheaths of the hair follicles
Overall higher relative accumulation of proteoglycans with Marilex®-P compared with Marilex®.
More rapid onset of Anagen induction in Telogen hair follicles

Conclusion:

Marilex®-P is more potent in terms of relative efficacy and speed of action than Marilex®.
Marilex®-P, demonstrates a more rapid Proteoglycan Replacement Therapy to FHG and PFA affected follicles.

Currently there are no clinical studies utilizing the higher dose of Marilex®-P.

Safety and Suitability

Is Hair Growth+ inCLINIC suitable for everyone?

Hair Growth+ inCLINIC is suitable for everyone except those with allergies to fish as Marilex-P is a marine-derived extract. Hair Growth+ inCLINIC does not contain shellfish.

Will patients experience growth of body or facial hair?

Hair Growth+ inCLINIC contains specific proteoglycans that are only involved in the hair follicle cycling of scalp hair. This means that Hair Growth+ inCLINIC does not affect the growth of body hair.

The proteoglycans in Marilex-P® are specific to scalp hair follicles. Whilst there are no specific direct clinical studies that are testing this parameter as a measurable result, any hair growth on the face or body parts whilst conducting any clinical study would have been noted as an unwanted side-effect.

With Marilex-P® being side-effect-free, then by virtue of the numerous subjective and objective trials conducted to date (on thousands of women) with no side effects and the anecdotal data available from the 30 year longevity of the product on the market, we have ample evidence to make this clear clinical observation of “no hair growth” on other parts of the body whilst being specific to scalp hairs only.

IMPORTANT NOTE: Minoxidil however, unlike Nourkrin®!!, can lead to hypertrichosis (unwanted hair growth on the face) even when limited to topical application on the scalp. Unwanted hair growth occurs more often in women than men; this is due to the existence of significantly more initial vellus hairs being converted to terminal hairs on the face / body of women than men. Studies have reported unwanted hair growth in up to 51% of female participants – it generally takes about 8 weeks for this hair growth to become visible. In some cases, women can develop generalized hypertrichosis, which is increased hair growth in areas not directly exposed to the treatment.

PATHOLOGICAL FACT TO HAVE IN MIND: Body hair, or androgenic hair, is the terminal hair that develops on the human body during and after puberty. It is differentiated from the head hair and less visible vellus hair, which is much finer and lighter in color.

Are there any side effects from taking Hair Growth+ inCLINIC?

Hair Growth+ inCLINIC is entirely based on drug-free ingredients which are evaluated as safe by the food and drug authorities globally. There have been no known side effects in the more than 30 years that Hair Growth+ inCLINIC has been available.

Can breastfeeding women take Hair Growth+ inCLINIC?

A: Hair Growth+ inCLINIC can be taken while breastfeeding, but patients are recommended to check with their doctors before starting the treatment.

Does Hair Growth+ inCLINIC interfere with any medication?

No, there are no known or registered instances of interference as Hair Growth+ inCLINIC is naturally based. However, if patients are on medication, they are recommended to check with their doctors before commencing with any supplement programme.

Can Hair Growth+ inCLINIC be taken for long periods?

Hair Growth+ inCLINIC is safe to take for indefinite periods and is ideal for long-term maintenance after the desired results have been achieved.

What happens if patients stop taking Hair Growth+ inCLINIC?

If patients’ hair loss is due to acute, temporary factors such as stress or hormonal changes, their results after 6 months may remain over time, given that these lifestyle factors have also been improved or changed. If their hair loss is related to DHT, genetics or is chronic, the condition may return after the treatment has ended.

Are any chemicals used in the process of distillation & condensation of Marilex-P?

There are no chemicals or solvents whatsoever used in the extraction, distillation, fractionation and condensation of Marilex-P.

The proprietary enzymatic hydrolysis extraction stages procuring Marilex® are conducted in water. Any purification stages are as a consequence of specific sequential heat treatment using water based techniques and drying – ultimately leading to a patented milling process during which the wished molecular size is achieved, thus ensuring optimum bioavailability.

(enzymatic hydrolysis extraction -This method uses specific enzymes to break down complex molecules into smaller, more bioavailable forms. Conducting this process in water helps maintain the integrity of the active compounds..)

Any side effects such as acne when first starting out on inCLINIC?

There are no side effects such as acne when first using Nourkrin®. The entire course is fully recommended and would not result in any dermatological side effects.

Viviscal, by nature is simply a very crude fish protein powder which is added to their formulation which is in essence merely a ‘multivitamin with fish protein’ so occasional reactions to those with more sensitive skin are commonly reported.

Nourkrin’s constitution and molecular profile is entirely different and circumvents such reactions as a Proteoglycan Replacement Therapy which uses a patented fractionation technique to isolate key proteoglycans from the raw material, and actually break down any crude proteins. ( eliminates proteins allergies that can be accumulated and caused with daily consumption )

Are there any contraindications for patients taking hydroxychloroquine?

There are no contraindications or interactions of Hair Growth+ inCLINIC with any medicines. Yes, it is a safe and natural product (not a drug). As such it is safe to use concomitantly with Hyrdroxychloroquine.