Trout fish DNA Polynucleotide (PN-HPT) vs. Salmon DNA Polynucleotide (PN) : A Comparative Look at Polynucleotide Skin Regeneration
In the ever-evolving world of aesthetic treatments, polynucleotide-based treatments like PN-HPT and PN have garnered attention for their promising effects in skin rejuvenation and repair. Both products are based on the science of polynucleotides, which are DNA fragments that support skin regeneration by stimulating cell repair and improving skin elasticity. Despite sharing a common goal—revitalising the skin—they differ significantly in their origins, composition, and user experience. In this article, we will take a balanced look at these differences to help clarify what makes each product distinct.
Origins and Composition
The primary difference between PN-HPT and PN lies in the source of the polynucleotides and their manufacturing process.
PN-HPT is a product that originates from Italy and uses DNA fragments extracted from trout fish, specifically farmed under stringent conditions to ensure safety and purity. Unlike wild-caught fish, the trout used for PN-HPT undergoes strict compliance protocols that guarantee its purity and consistency. This careful farming process is essential, assuring that the polynucleotides are free from contaminants and derived from an ethically monitored source. In addition, PN-HPT has the distinction of being the original polynucleotide treatment, developed in Italy.
PN-HPT also offers itself in a slightly different composition as treatment that’s more suitable for delicate skin. PN-HPT is more suitable for the face, which helps with the biorevitalisation of the face to aid with damaged and ageing skin. On the other hand, PN-HPT Fast is designed for skin quality improvement on thin and delicate areas such as the periocular area (around the eyes). It helps to revive tired-looking eyes and reduces superficial wrinkles and fine lines around the delicate skin area. Both can be used concurrently in the same session targeting different parts of the face.
PN is derived from salmon DNA. The polynucleotides extracted have been utilised in various aesthetic treatments to promote skin healing and improve elasticity.
Safety and Purity
The sourcing and farming methods of the fish used in both products also differentiate PN-HPT from PN.
PN-HPT uses farmed trout with rigorous compliance measures to ensure its purity. The controlled environment in which the trout are raised ensures that they are free from pollutants, disease, and other factors that could compromise the quality of the polynucleotides. This distinction may be particularly reassuring for users who prioritise the purity and traceability of the ingredients in their aesthetic treatments.
For patients with particularly sensitive skin or prone to allergic reactions, PN-HPT may be a more suitable option owing to its purity of polynucleotides that are free from contaminants.
Mechanisms of Action
Both PN-HPT and PN aims to use polynucleotides targeting fibroblast to improve the skin’s collagen and elastin production, which are essential for maintaining firm and youthful skin. However, PN-HPT is shared to be more consistent in its overall results, having superior improvement in
* Atrophic acne scars
* Hydration
* Skin firming and tightening
* Sensitive skin, such as rosacea
* Overall skin texture, such as pores and fine lines
PN-HPT is clinically proven to help improve 15% in hydration, 22% in elasticity, 60% in collagen production1 and increase in Type I and Type III collagen2. Overall, it provides a holistic improvement to your skin health and has high compatibility with other aesthetic treatments that you may be doing concurrently.
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1Cavallini M, Papagni M. Long chain polynucleotides gel and skin biorevitalization. Journal of Plastic Dermatology 2007; 3(3): 27-32
2M T Colangelo , P Govoni , S Belletti , F Squadrito , S Guizzardi , C Galli. Polynucleotide biogel enhances tissue repair, matrix deposition and organization. J Biol Regul Homeost Agents. Jan Feb 2021; 35(1): 355-362